Betaloc Zok Use In Pregnancy & Lactation

Pregnancy: Betaloc ZOK should only be given during pregnancy and lactation when use is considered essential. In general, β-blockers reduce placental perfusion, which has been associated with growth retardation, intrauterine death, abortion and early labour. It is therefore suggested that appropriate maternofetal monitoring be performed in pregnant women treated with metoprolol. Beta-receptor blockers may cause bradycardia in the foetus and in the new-born infant. This should be considered if these drugs are prescribed in the last trimester and in association with delivery. Betaloc ZOK should gradually be withdrawn 48-72 hours before planned childbirth. If this is not possible the newborn infant should be supervised during 48-72 hours postpartum for signs and symptoms of beta-blockade (e.g. heart- and lung complications).
Lactation: Metoprolol is concentrated in human breast milk in a quantity that corresponds to approximately three times the quantity found in the plasma of the mother. The risk for harmful reactions with respect to the breastfeeding child seems to be low at therapeutic doses of the medicine. The breast-feeding child should however be observed regarding signs of betablockade.